The goal is to introduce students to the basic statistical methods and their application to simple problems. The topics include:

•          Chi square test

•          Simple regression and correlation

•          Multiple regression and correlation

•          One way analysis of variance

•          Two way analysis of variance

•          Discriminant analysis

•          Analysis of categorial data

•          Chossing the appropriate statistical method

•          Determining critical sample sizes

Applied Regression Analysis and Multivariable Methods, 3rd Edition, David G. Kleinbaum Emory University, Lawrence L. Kupper University of North Carolina at Chapel Hill, Keith E. Muller University of North Carolina at Chapel Hill, Azhar Nizam Emory University, Published by Duxbury Press, CB © 1998, ISBN/ISSN: 0-534-20910-6

The students receive a problem task, which they have to solve in small groups (n=5). They do have to collect their own data and work with them. The results have to be presented in an executive summary at the end of the course.

Selbst zu finden

The different statistical tests are applied for the solution of realistic problems using actual data sets and the most common used commercial statistical software package (SPSS).

Student Solutions Manual for Kleinbaum/Kupper/Muller/Nizam's Applied Regression Analysis and Multivariable Methods, 3rd Edition, David G. Kleinbaum Emory University Lawrence L. Kupper University of North Carolina at Chapel Hill, Keith E. Muller University of North Carolina at Chapel Hill, Azhar Nizam Emory University, Published by Duxbury Press, Paperbound © 1998, ISBN/ISSN: 0-534-20913-0

• Theories and methods of project management
• Innovation management
• Agile project management
• Fundamentals of classic and agile methods
• Hybrid use of classic and agile methods  
• Roles, perspectives and stakeholders throughout the project
• Initiating and coordinating complex engineering projects
• Principles of moderation, team management, team leadership, conflict management
• Communication structures: in-house, cross-company
• Public information policy
• Promoting commitment and empowerment
• Sharing experience with specialists and managers from the engineering sector
• Documenting and reflecting on learning experiences

Seminarapparat

• Basic concepts, opportunities and limits of organisational change 
• Models and methods of organisational design and development
• Strategic orientation and change, and their short-, medium- and long-term consequences for individuals, organisations and society as a whole
• Roles, perspectives and stakeholders in change processes
• Initiating and coordinating change measures in engineering
• Phase models of organisational change (Lewin, Kotter, etc.) 
• Change-oriented information policy and dealing with resistance and uncertainty 
• Promoting commitment and empowerment
• Successfully handling change and transformation: personally, as an employee, as a manager (personal, professional, organisational)
• Company-level and globally (systemic)
• Sharing experience with specialists and managers from the engineering sector
• Documenting and reflecting on learning experiences

Company onboarding process

• Assigning a professional field of activity as an engineer (B.Sc.) and associated fields of work
• Establishing responsibilities and authorisation of the dual student within the company as an engineer (B.Sc.)
• Working independently in a team and on selected projects - across departments and, if applicable, across companies
• Scheduling the current practical module with a clear correlation to work structures 
• Scheduling the examination phase/subsequent study semester

Operational knowledge and skills

• Company-specific: Responsibility as an engineer (B.Sc.) in their own area of work, coordinating team and project work, dealing with complex contexts and unsolved problems, developing and implementing innovative solutions
• Subject specialisation (corresponding to the chosen course [M.Sc.]) in the field of activity
• Systemic skills
• Implementing the university’s application recommendations (theory-practice transfer) in corresponding work and task areas across the company 

Sharing/reflecting on learning

• Creating an e-portfolio
• Importance of course contents (M.Sc.) when working as an engineer
• Importance of development and innovation when working as an engineer
  

• Studierendenhandbuch
• Betriebliche Dokumente
• Hochschulseitige Handlungsempfehlungen zum Theorie-Praxis-Transfer

Primary book:

1. P. Suetens, "Fundamentals of Medical Imaging", Cambridge Press

Secondary books:

- A. Webb, "Introduction to Biomedical Imaging", IEEE Press 2003.

- W.R. Hendee and E.R. Ritenour, "Medical Imaging Physics", Wiley-Liss, New York, 2002.

- H. Morneburg (Edt), "Bildgebende Systeme für die medizinische Diagnostik", Erlangen: Siemens Publicis MCD Verlag, 1995.

- O. Dössel, "Bildgebende Verfahren in der Medizin", Springer Verlag Berlin, 2000.

Product Development:

• Modal analysis - experimental and computational
  
• Appropriate design in engineering
• Characterization of rubbery-elastic materials
• Stick-Slip-Analysis at friction and wear test station
  

Materials:

• Property profiles of steel
• Actuators for modern fuel injection systems - synthesis and properties
  
• Processing, properties and structure of thermoplastic polymers and its composites
• Tribology in joints
  

Production:

• Optimization of welding process parameters for hybrid plasma laser welding
• Evaluation of stock removal processes
• Analysis of basic laws in production logistics
• Analysis of positioning behaviour and trajectory accuracy of industrial robots

Nach Themenstellung / depending on topic

Upon successful completion of the course, participants should be able to describe the foundations of the organization of the German health system and to describe different ways of treatment in the hospital. They should be able to describe the anatomy, physiology and basic diagnostic possibilities for the following organ system: heart / circulatory system, lungs, digestive tract, kidney, including the technical possibilities of monitoring heart-lung function, in the emergency department,in the monitoring stations and in intensive care and the basics of cardiopulmonary resuscitation. Furthermore, the anatomy and physiology of the nervous system will be explored. The importance and possibilities of preventive medicine of serious public health problems are described. Students prepare their own sub-themes in the form of small lectures and discuss various clinical cases on these topics interactively as problem-based learning.This course/Lecture by excursions into our emergency room, our endoscopy unit, mini-laparoscopy and our ICU as well as out patient clinics.

Wird in der Veranstaltung bekannt gegeben

Major diseases of

• the gastrointestinal system and the liver,
• the hormone system,
• the kidneys.

The lecture will focus on pathophysiology, symptoms, diagnostic and therapeutic principles of these diseases.

I Gastrointestinal tract and liver:

• Gastrointestinal bleeding: causes, symptoms, endoscopic treatment options
• Colorectal cancer: basics, principle of prophylactic screening, therapy
• Liver diseases / liver cirrhosis: causes, symptoms, complications, therapeutic options

II Hormones:

• Diabetes mellitus type 1 and 2: pathophysiology, complications, basics of glucose metabolism, therapeutic principles
• Thyreoid gland - hyper- and hypothyreoidism: causes, symptoms diagnostics, therapy

III Kidneys         

• Functions and failure, diagnostics, principles of renal replacement therapy

a) Basic understanding of the pathology/pathophysiology of cardiac diseases and their stage-adapted treatments: coronary heart disease, myocardial infarction, mitral valve insufficiencies, aortic valve stenosis

b) Basic understanding of the pathology/pathophysiology of pulmonary diseases and their stage-adapted treatments: asthma, chronic obstructive pulmonary disease, pneumonia, bronchial cancer

c) Basic understanding of infectious diseases, immune-system and autoimmune diseases

Skript zur Vorlesung.

Die Fallstudien werden in einem 2-wöchentlichen Blockkurs in der Innere und Chirurgie demonstriert. Alle 1-2 Tage wechseln die Stationen hierzu gehören:

-           Notaufnahme

-           Intensivstation

-           Pneumologie

-           Gastroenterologie

-           Kardiologie

-           Transfusionsmedizin

-           Poliklinik/Ambulanz

-           Dialyse

-           Unfallchirugie

The students complete a 1-week clinical internship in a hospital.

The students organize the execution of the clinical internship in a hospital self-reliant. The choice of hospital has to be agreed with the program director.

Company onboarding process

• Assigning a professional field of activity as an engineer (B.Sc.) and associated fields of work
• Establishing responsibilities and authorisation of the dual student within the company as an engineer (B.Sc.)
• Taking personal responsibility within a team and on selected projects - across departments and, if applicable, across companies
• Scheduling the current practical module with a clear correlation to work structures 
• Scheduling the examination phase/subsequent study semester

Operational knowledge and skills

• Company-specific: Responsibility as an engineer (B.Sc.) in their own area of work, coordinating team and project work, dealing with complex contexts and unsolved problems, developing and implementing innovative solutions
• Subject specialisation (corresponding to the chosen course [M.Sc.]) in the field of activity
• Systemic skills
• Implementing the university’s application recommendations (theory-practice transfer) in corresponding work and task areas across the company 

Sharing/reflecting on learning

• Updating their e-portfolio
• Importance of course contents (M.Sc.) when working as an engineer
• Importance of development and innovation when working as an engineer 

• Studierendenhandbuch
• Betriebliche Dokumente
• Hochschulseitige Anwendungsempfehlungen zum Theorie-Praxis-Transfer

Company onboarding process

• Assigning a future professional field of activity as an engineer (M.Sc.) and associated fields of work
• Extending responsibilities and authorisation of the dual student within the company up to the intended first assignment after completing their studies 
• Working responsibly in a team; project responsibility within own area - as well as across divisions and companies if necessary
• Scheduling the final practical module with a clear correlation to work structures 
• Internal agreement on a potential topic or innovation project for the Master’s dissertation
• Planning the Master’s dissertation within the company in cooperation with TU Hamburg  
• Scheduling the examination phase/subsequent study semester

Operational knowledge and skills

• Company-specific: dealing with change, project and team development, responsibility as an engineer in their future field of work (M.Sc.), dealing with complex contexts, frequent and unpredictable changes, developing and implementing innovative solutions
• Specialising in one field of work (final dissertation)
• Systemic skills
• Implementing the university’s application recommendations (theory-practice transfer) in corresponding work and task areas across the company 

Sharing/reflecting on learning

• E-portfolio
• Relevance of study content and personal specialisation when working as an engineer
• Relevance of research and innovation when working as an engineer

• Studierendenhandbuch
• betriebliche Dokumente
• Hochschulseitige Anwendungsempfehlungen zum Theorie-Praxis-Transfer

- methods for search, optimization,  planning,  classification, regression and prediction in a clinical context
- representation of medical knowledge
- understanding challenges due to clinical and patient related data and data acquisition
The students will work in groups to apply the methods introduced during the lecture using problem based learning.

Russel & Norvig: Artificial Intelligence: a Modern Approach, 2012
Berner: Clinical Decision Support Systems: Theory and Practice, 2007
Greenes: Clinical Decision Support: The Road Ahead, 2007
Further literature will be given in the lecture

Biological materials are omnipresent in the world around us. They are the main constituents in plant and animal bodies and have a diversity of functions. A fundamental function is obviously mechanical providing protection and support for the body. But biological materials may also serve as ion reservoirs (bone is a typical example), as chemical barriers (like cell membranes), have catalytic function (such as enzymes), transfer chemical into kinetic energy (such as the muscle), etc.This lecture will focus on materials with a primarily (passive) mechanical function: cellulose tissues (such as wood), collagen tissues (such as tendon or cornea), mineralized tissues (such as bone, dentin and glass sponges). The main goal is to give an introduction to the current knowledge of the structure in these materials and how these structures relate to their (mostly mechanical) functions.

Peter Fratzl, Richard Weinkamer, Nature’s hierarchical materialsProgress,  in Materials Science 52 (2007) 1263-1334

Journal publications

This course is intended as an introduction to the topics of wave propagation, guiding, sending, and receiving as well as Electromagnetic Compatibility (EMC). It will be useful for engineers that face the technical challenge of transmitting high frequency / high bandwidth data in e.g. medical, automotive, or avionic applications. Both circuit and field concepts of wave propagation and Electromagnetic Compatibility will be introduced and discussed.

Topics:

- Fundamental properties and phenomena of electrical circuits
- Steady-state sinusoidal analysis of electrical circuits
- Fundamental properties and phenomena of electromagnetic fields and waves
- Steady-state sinusoidal description of electromagnetic fields and waves
- Useful microwave network parameters
- Transmission lines and basic results from transmission line theory
- Plane wave propagation, superposition, reflection and refraction
- General theory of waveguides
- Most important types of waveguides and their properties
- Radiation and basic antenna parameters
- Most important types of antennas and their properties
- Numerical techniques and CAD tools for waveguide and antenna design
- Fundamentals of Electromagnetic Compatibility
- Coupling mechanisms and countermeasures
- Shielding, grounding, filtering
- Standards and regulations
- EMC measurement techniques

- Zinke, Brunswig, "Hochfrequenztechnik 1", Springer (1999)

- J. Detlefsen, U. Siart, "Grundlagen der Hochfrequenztechnik", Oldenbourg (2012)

- D. M. Pozar, "Microwave Engineering", Wiley (2011)

- Y. Huang, K. Boyle, "Antenna: From Theory to Practice", Wiley (2008)

- H. Ott, "Electromagnetic Compatibility Engineering", Wiley (2009)

- A. Schwab, W. Kürner, "Elektromagnetische Verträglichkeit", Springer (2007)

The course deals with common experimental methods used in biomechanics. For each topic an overview and some basic practical knowledge is provided.

1. Tribology
2. Optical Methods
3. Motion Analysis
4. Pressure Distribution
5. Strain Gauges
6. Pre-clinical testing
7. Specimen Preparation and Storage

Hoffmann K., Eine Einführung in die Technik des Messens mit Dehnmessstreifen

White A.A., Panjabi M.M.: Clinical biomechanics of the spine

Nigg, B.: Biomechanics of the musculo-skeletal system

Online Hilfe von Mathworks: https://de.mathworks.com/help/matlab/

• Structural characterization by photons, neutrons and electrons (in particular X-ray and neutron scattering, electron microscopy, tomography)
• Mechanical and thermodynamical characterization methods (indenter measurements, mechanical compression and tension tests, specific heat measurements)
  

• Characterization of optical, electrical and magnetic properties (spectroscopy, electrical conductivity and magnetometry)

  
  

William D. Callister und David G. Rethwisch, Materialwissenschaften und Werkstofftechnik, Wiley&Sons, Asia (2011).

William D. Callister, Materials Science and Technology, Wiley& Sons, Inc. (2007).

• Vorkenntnisse aus „ Diskretisierungsmethoden der Mechanik“ sind empfohlen
• Ein Überblick über die gängigsten numerischen Verfahren im Bereich der Biomechanik und Medizintechnik wird vermittelt.
• Grundkenntnissen aus verschiedenen Disziplinen (Mechanik, Mathematik, Programmierung…) werden kombiniert um eine geschlossene Beispielfragestellung zu beantworten
• Die Vorlesung umfasst analytische Ansätze, rheologische Modelle und Finite Elemente Methoden
• Die vermittelten theoretischen Ansätze werden im Laufe der Vorlesung und im Rahmen von Hausaufgaben in praktische Übungen angewandt.
• Der kritische Blick auf die Möglichkeiten und Limitationen der Modellrechnung im Bereich humaner Anwendungen wird geschult.

Hauger W., Schnell W., Gross D., Technische Mechanik, Band 3: Kinetik, Springer-Verlag Berlin Heidelberg, 12. Auflage, 2012

Huber G., de Uhlenbrock A., Götzen N., Bishop N., Schwieger K., Morlock MM., Modellierung, Simulation und Optimierung, Handbuch Sportbiomechanik, Gollhofer A., Müller E., Hofmann Verlag, Schorndorf, 148-69, 2009

At the beginning of the semester, the participants receive a research question from medical engineering or related fields, which they have to work on independently. The researched results are summarised in a written report and presented in a lecture. The evaluation is 30:70 (report:presentation). The participants must secretly evaluate each other and these evaluations are included in the final grade. The presentations are discussed directly afterwards in terms of presentation style, appearance and language.

• Differential equations for momentum-, heat and mass transfer   
• Examples for simplifications of the Navier-Stokes Equations 
• Unsteady momentum transfer
  
• Free shear layer, turbulence and free jets
  
• Flow around particles - Solids Process Engineering
  
• Coupling of momentum and heat transfer - Thermal Process Engineering
  
• Rheology – Bioprocess Engineering
• Coupling of momentum- and mass transfer – Reactive mixing, Chemical Process Engineering 
• Flow threw porous structures - heterogeneous catalysis
  
• Pumps and turbines - Energy- and Environmental Process Engineering 
• Wind- and Wave-Turbines - Renewable Energy
• Introduction into Computational Fluid Dynamics
  
  

1. Brauer, H.: Grundlagen der Einphasen- und Mehrphasenströmungen. Verlag Sauerländer, Aarau, Frankfurt (M), 1971.
2. Brauer, H.; Mewes, D.: Stoffaustausch einschließlich chemischer Reaktion. Frankfurt: Sauerländer 1972.
3. Crowe, C. T.: Engineering fluid mechanics. Wiley, New York, 2009.
4. Durst, F.: Strömungsmechanik: Einführung in die Theorie der Strömungen von Fluiden. Springer-Verlag, Berlin, Heidelberg, 2006.
5. Fox, R.W.; et al.: Introduction to Fluid Mechanics. J. Wiley & Sons, 1994.
6. Herwig, H.: Strömungsmechanik: Eine Einführung in die Physik und die mathematische Modellierung von Strömungen. Springer Verlag, Berlin, Heidelberg, New York, 2006.
7. Herwig, H.: Strömungsmechanik: Einführung in die Physik von technischen Strömungen: Vieweg+Teubner Verlag / GWV Fachverlage GmbH, Wiesbaden, 2008.
8. Kuhlmann, H.C.:  Strömungsmechanik. München, Pearson Studium, 2007
9. Oertl, H.: Strömungsmechanik: Grundlagen, Grundgleichungen, Lösungsmethoden, Softwarebeispiele. Vieweg+ Teubner / GWV Fachverlage GmbH, Wiesbaden, 2009.
10. Schade, H.; Kunz, E.: Strömungslehre. Verlag de Gruyter, Berlin, New York, 2007.
11. Truckenbrodt, E.: Fluidmechanik 1: Grundlagen und elementare Strömungsvorgänge dichtebeständiger Fluide. Springer-Verlag, Berlin, Heidelberg, 2008.
12. Schlichting, H. : Grenzschicht-Theorie. Springer-Verlag, Berlin, 2006.
13. van Dyke, M.: An Album of Fluid Motion. The Parabolic Press, Stanford California, 1882.  

• Definition of agents, rational behavior, goals, utilities, environment types
• Adversarial agent cooperation: 
  Agents with complete access to the state(s) of the environment, games, Minimax algorithm, alpha-beta pruning, elements of chance
• Uncertainty: 
  Motivation: agents with no direct access to the state(s) of the environment, probabilities, conditional probabilities, product rule, Bayes rule, full joint probability distribution, marginalization, summing out, answering queries, complexity, independence assumptions, naive Bayes, conditional independence assumptions
• Bayesian networks: 
  Syntax and semantics of Bayesian networks, answering queries revised (inference by enumeration), typical-case complexity, pragmatics: reasoning from effect (that can be perceived by an agent) to cause (that cannot be directly perceived).
• Probabilistic reasoning over time:
  Environmental state may change even without the agent performing actions, dynamic Bayesian networks, Markov assumption, transition model, sensor model, inference problems: filtering, prediction, smoothing, most-likely explanation, special cases: hidden Markov models, Kalman filters, Exact inferences and approximations
• Decision making under uncertainty:
  Simple decisions: utility theory, multivariate utility functions, dominance, decision networks, value of informatio
  Complex decisions: sequential decision problems, value iteration, policy iteration, MDPs
  Decision-theoretic agents: POMDPs, reduction to multidimensional continuous MDPs, dynamic decision networks
  
• Simultaneous Localization and Mapping
  
• Planning
• Game theory (Golden Balls: Split or Share) 
  Decisions with multiple agents, Nash equilibrium, Bayes-Nash equilibrium
• Social Choice 
  Voting protocols, preferences, paradoxes, Arrow's Theorem,
• Mechanism Design 
  Fundamentals, dominant strategy implementation, Revelation Principle, Gibbard-Satterthwaite Impossibility Theorem, Direct mechanisms, incentive compatibility, strategy-proofness, Vickrey-Groves-Clarke mechanisms, expected externality mechanisms, participation constraints, individual rationality, budget balancedness, bilateral trade, Myerson-Satterthwaite Theorem

1. Artificial Intelligence: A Modern Approach (Third Edition), Stuart Russell, Peter Norvig, Prentice Hall, 2010, Chapters 2-5, 10-11, 13-17

2. Probabilistic Robotics, Thrun, S., Burgard, W., Fox, D. MIT Press 2005

3. Multiagent Systems: Algorithmic, Game-Theoretic, and Logical Foundations, Yoav Shoham, Kevin Leyton-Brown, Cambridge University Press, 2009

Linear and Nonlinear Single and Multiple Degree of Freedom Vibrations

• Free vibration
• Self-excited vibration
• Parameter driven vibration
• Forced vibration
• Multi degree of freedom vibration
• Continuum vibration
• Irregular vibration

German - K. Magnus, K. Popp, W. Sextro: Schwingungen. Physikalische Grundlagen und mathematische Behandlung von Schwingungen.

English - K. Magnus: Vibrations. 

- General overview on modern engineering
- Displacement method
- Hybrid formulation
- Isoparametric elements
- Numerical integration
- Solving systems of equations (statics, dynamics)
- Eigenvalue problems
- Non-linear systems
- Applications

- Programming of elements (Matlab, hands-on sessions)
- Applications

Bathe, K.-J. (2000): Finite-Elemente-Methoden. Springer Verlag, Berlin

The role of technology for the competitive advantage of the firm and industries; Basic concepts, models and tools for the management of technology; managerial decision making regarding the identification, selection and protection of technology (make or buy, keep or sell, current and future technologies). Theories, practical examples (cases), lectures, interactive sessions and group study.

This lecture is part of the Module Technology Management and can not separately choosen.

Beside the written exam at the end of the module, students have to give one presentation (RE) on a research paper and two presentations as part of a group discussion (GD) in the seminar in order to pass. With these presentations it is possible to gain a bonus of max. 20% for the exam. However, the bonus is only valid if the exam is passed without the bonus.

• Introduction (historical view, scientific and economic relevance, scaling laws)
• Semiconductor Technology Basics, Lithography (wafer fabrication, photolithography, improving resolution, next-generation lithography, nano-imprinting, molecular imprinting)
• Deposition Techniques (thermal oxidation, epitaxy, electroplating, PVD techniques: evaporation and sputtering; CVD techniques: APCVD, LPCVD, PECVD and LECVD; screen printing)
• Etching and Bulk Micromachining (definitions, wet chemical etching, isotropic etch with HNA, electrochemical etching, anisotropic etching with KOH/TMAH: theory, corner undercutting, measures for compensation and etch-stop techniques; plasma processes, dry etching: back sputtering, plasma etching, RIE, Bosch process, cryo process, XeF2 etching)
• Surface Micromachining and alternative Techniques (sacrificial etching, film stress, stiction: theory and counter measures; Origami microstructures, Epi-Poly, porous silicon, SOI, SCREAM process, LIGA, SU8, rapid prototyping)
• Thermal and Radiation Sensors (temperature measurement, self-generating sensors: Seebeck effect and thermopile; modulating sensors: thermo resistor, Pt-100, spreading resistance sensor, pn junction, NTC and PTC; thermal anemometer, mass flow sensor, photometry, radiometry, IR sensor: thermopile and bolometer)
• Mechanical Sensors (strain based and stress based principle, capacitive readout, piezoresistivity,  pressure sensor: piezoresistive, capacitive and fabrication process; accelerometer: piezoresistive, piezoelectric and capacitive; angular rate sensor: operating principle and fabrication process)
• Magnetic Sensors (galvanomagnetic sensors: spinning current Hall sensor and magneto-transistor; magnetoresistive sensors: magneto resistance, AMR and GMR, fluxgate magnetometer)
• Chemical and Bio Sensors (thermal gas sensors: pellistor and thermal conductivity sensor; metal oxide semiconductor gas sensor, organic semiconductor gas sensor, Lambda probe, MOSFET gas sensor, pH-FET, SAW sensor, principle of biosensor, Clark electrode, enzyme electrode, DNA chip)
• Micro Actuators, Microfluidics and TAS (drives: thermal, electrostatic, piezo electric and electromagnetic; light modulators, DMD, adaptive optics, microscanner, microvalves: passive and active, micropumps, valveless micropump, electrokinetic micropumps, micromixer, filter, inkjet printhead, microdispenser, microfluidic switching elements, microreactor, lab-on-a-chip, microanalytics)
• MEMS in medical Engineering (wireless energy and data transmission, smart pill, implantable drug delivery system, stimulators: microelectrodes, cochlear and retinal implant; implantable pressure sensors, intelligent osteosynthesis, implant for spinal cord regeneration)
• Design, Simulation, Test (development and design flows, bottom-up approach, top-down approach, testability, modelling: multiphysics, FEM and equivalent circuit simulation; reliability test, physics-of-failure, Arrhenius equation, bath-tub relationship)
• System Integration (monolithic and hybrid integration, assembly and packaging, dicing, electrical contact: wire bonding, TAB and flip chip bonding; packages, chip-on-board, wafer-level-package, 3D integration, wafer bonding: anodic bonding and silicon fusion bonding; micro electroplating, 3D-MID)

M. Madou: Fundamentals of Microfabrication, CRC Press, 2002

N. Schwesinger: Lehrbuch Mikrosystemtechnik, Oldenbourg Verlag, 2009

T. M. Adams, R. A. Layton:Introductory MEMS, Springer, 2010

G. Gerlach; W. Dötzel: Introduction to microsystem technology, Wiley, 2008

State space methods (single-input single-output)

• State space models and transfer functions, state feedback 
• Coordinate basis, similarity transformations 
• Solutions of state equations, matrix exponentials, Caley-Hamilton Theorem
• Controllability and pole placement 
• State estimation, observability, Kalman decomposition 
• Observer-based state feedback control, reference tracking 
• Transmission zeros
• Optimal pole placement, symmetric root locus 
Multi-input multi-output systems
• Transfer function matrices, state space models of multivariable systems, Gilbert realization 
• Poles and zeros of multivariable systems, minimal realization 
• Closed-loop stability
• Pole placement for multivariable systems, LQR design, Kalman filter 

Digital Control
• Discrete-time systems: difference equations and z-transform 
• Discrete-time state space models, sampled data systems, poles and zeros 
• Frequency response of sampled data systems, choice of sampling rate 

System identification and model order reduction 
• Least squares estimation, ARX models, persistent excitation 
• Identification of state space models, subspace identification 
• Balanced realization and model order reduction 

Case study
• Modelling and multivariable control of a process evaporator using Matlab and Simulink 
Software tools
• Matlab/Simulink

• Werner, H., Lecture Notes „Control Systems Theory and Design“
• T. Kailath "Linear Systems", Prentice Hall, 1980
• K.J. Astrom, B. Wittenmark "Computer Controlled Systems" Prentice Hall, 1997
• L. Ljung "System Identification - Theory for the User", Prentice Hall, 1999

Due to the developments of Industry 4.0, digitalization and interconnectivity become a strategic advantage for companies in the international competition. This lecture focuses on the relevant modules and enables the participants to evaluate current developments in this context. In particular, knowledge management, simulation, process modelling and virtual technologies are covered.

Content:

• Business Process Management and Data Modelling, Simulation
• Knowledge and Competence Management
• Process Management (PPC, Workflow Management)
• Computer Aided Planning (CAP) and NC-Programming
• Virtual Reality (VR) and Augmented Reality (AR)
• Computer Aided Quality Management (CAQ) 
• Industry 4.0

Scheer, A.-W.: ARIS - vom Geschäftsprozeß zum Anwendungssystem. Springer-Verlag, Berlin 4. Aufl. 2002

Schuh, G. et. al.: Produktionsplanung und -steuerung, Springer-Verlag. Berlin 3. Auflage 2006

Becker, J.; Luczak, H.: Workflowmanagement in der Produktionsplanung und -steuerung. Springer-Verlag, Berlin 2004

Pfeifer, T; Schmitt, R.: Masing Handbuch Qualitätsmanagement. Hanser-Verlag, München 5. Aufl. 2007 

Kühn, W.: Digitale Fabrik. Hanser-Verlag, München 2006

• Models of Production and Inventory Management
• Production Programme Planning and Lot Sizing
• Order and Capacity Scheduling
• Selected Strategies of PPC
• Manufacturing Control
• Production Controlling
• Supply Chain Management

• Vorlesungsskript
• Lödding, H: Verfahren der Fertigungssteuerung, Springer 2008
• Nyhuis, P.; Wiendahl, H.-P.: Logistische Kennlinien, Springer 2002

See interlocking course

Siehe korrespondierende Vorlesung

See interlocking course

Continuum mechanics is a general theory to describe the effect of mechanical forces on continuous mechanical (both solid and fluid) bodies. An important part of continuum mechanics is the mathematical description of strains and stresses as well as the stress-strain response of continuous mechanical bodies. The lecture continuum mechanics builds on the foundations tought in the lecture Engineering Mechanics II (Elastostatics) but extends them significantly. While in the lecture Engineering Mechanics II (Elastostatics) the focus was by and large limited to small deformations of simple bodies under simple loading, the lecture continuum mechanics introduces a general mathematical framework to deal with arbitrarily shaped bodies under arbitrary loading undergoing very general kinds of deformations. This lecture focuses primarily on theoretical aspects of continuum mechanics but its content is key to numerous applications in modern engineering, for example, in production, automotive, and biomedical engineering. The lecture covers:

• Fundamentals of tensor calculus
  • Transformation invariance
  • Tensor algebra
  • Tensor analysis
    
• Kinematics
  • Motion of continuum
  • Deformation of infinitesimal line, area and volume elements
  • Material and spatial description
  • Polar decomposition
  • Spectral decomposition
    
  • Objectivity
  • Strain measures
  • Time derivatives
    • Partial / material time derivatives
    • Objective time rates
    • Strain and deformation rates
      
  • Transport theorems
    
• Balance equations (global and local form)
  • Balance of mass
  • The stress state
    • Surface traction vectors
    • Cauchy's fundamental theorem
    • Stress tensors (Cauchy, 1. and 2. Piola-Kirchhoff, Kirchhoff stress tensor)
  • Balance of linear momentum
  • Balance of angular momentum
  • Balance of energy
  • Balance of entropy
  • Clausius-Duhem inequality
• Constitutive laws
  • Constitutive assumptions
  • Fluids
  • Elastic solids
    • Hyperelasticity
    • Material symmetry
  • Elasto-plastic solids
    
• Analysis
  
  • Initial-boundary value problems and their numerical solution 

R. Greve: Kontinuumsmechanik: Ein Grundkurs für Ingenieure und Physiker

I-S. Liu: Continuum Mechanics, Springer

R. Greve: Kontinuumsmechanik: Ein Grundkurs für Ingenieure und Physiker

I-S. Liu: Continuum Mechanics, Springer

One of the most important questions when modeling mechanical systems in practice is how to model the behavior of the materials of their different components. In addition to simple isotropic elasticity in particular the following phenomena play key roles

- anisotropy (material behavior depending on direction, e.g., in fiber-reinforced materials)
- plasticity (permanent deformation due to one-time overload, e.g., in metal forming)
- viscoelasticity (absorption of energy, e.g., in dampers)
- creep (slow deformation under permanent load, e.g., in pipes)

This lecture briefly introduces the theoretical foundations and mathematical modeling of the above phenomena. It is complemented by exercises where simple examples problems are solved by calculations and where the implementation of the content of the lecture in computer simulations is explained. It will also briefly discussed how important material parameters can be determined from experimental data.

Empfohlene Literatur / Recommended literature:
1) Dietmar Gross, Werner Hauger, Peter Wriggers, Technische Mechanik 4, Springer 2018, DOI: 10.1007/978-3-662-55694-8
2) Peter Haupt, Continuum Mechanics and Theory of Materials, Springer 2002, DOI: 10.1007/978-3-662-04775-0

1. Porous Solids - Preparation, Characterization and Functionalities
2. Fluidics with nanoporous membranes
3. Thermoplastic elastomers
4. Optimization of polymer properties by nanoparticles
5. Fiber composites in automotive
6. Modeling of materials based on quantum mechanics
7. Biomaterials

Aktuelle Publikationen aus der Fachliteratur werden während der Veranstaltung bekanntgegeben.

Biological materials are omnipresent in the world around us. They are the main constituents in plant and animal bodies and have a diversity of functions. A fundamental function is obviously mechanical providing protection and support for the body. But biological materials may also serve as ion reservoirs (bone is a typical example), as chemical barriers (like cell membranes), have catalytic function (such as enzymes), transfer chemical into kinetic energy (such as the muscle), etc.This lecture will focus on materials with a primarily (passive) mechanical function: cellulose tissues (such as wood), collagen tissues (such as tendon or cornea), mineralized tissues (such as bone, dentin and glass sponges). The main goal is to give an introduction to the current knowledge of the structure in these materials and how these structures relate to their (mostly mechanical) functions.

Peter Fratzl, Richard Weinkamer, Nature’s hierarchical materialsProgress,  in Materials Science 52 (2007) 1263-1334

Journal publications

This course is intended as an introduction to the topics of wave propagation, guiding, sending, and receiving as well as Electromagnetic Compatibility (EMC). It will be useful for engineers that face the technical challenge of transmitting high frequency / high bandwidth data in e.g. medical, automotive, or avionic applications. Both circuit and field concepts of wave propagation and Electromagnetic Compatibility will be introduced and discussed.

Topics:

- Fundamental properties and phenomena of electrical circuits
- Steady-state sinusoidal analysis of electrical circuits
- Fundamental properties and phenomena of electromagnetic fields and waves
- Steady-state sinusoidal description of electromagnetic fields and waves
- Useful microwave network parameters
- Transmission lines and basic results from transmission line theory
- Plane wave propagation, superposition, reflection and refraction
- General theory of waveguides
- Most important types of waveguides and their properties
- Radiation and basic antenna parameters
- Most important types of antennas and their properties
- Numerical techniques and CAD tools for waveguide and antenna design
- Fundamentals of Electromagnetic Compatibility
- Coupling mechanisms and countermeasures
- Shielding, grounding, filtering
- Standards and regulations
- EMC measurement techniques

- Zinke, Brunswig, "Hochfrequenztechnik 1", Springer (1999)

- J. Detlefsen, U. Siart, "Grundlagen der Hochfrequenztechnik", Oldenbourg (2012)

- D. M. Pozar, "Microwave Engineering", Wiley (2011)

- Y. Huang, K. Boyle, "Antenna: From Theory to Practice", Wiley (2008)

- H. Ott, "Electromagnetic Compatibility Engineering", Wiley (2009)

- A. Schwab, W. Kürner, "Elektromagnetische Verträglichkeit", Springer (2007)

The course deals with common experimental methods used in biomechanics. For each topic an overview and some basic practical knowledge is provided.

1. Tribology
2. Optical Methods
3. Motion Analysis
4. Pressure Distribution
5. Strain Gauges
6. Pre-clinical testing
7. Specimen Preparation and Storage

Hoffmann K., Eine Einführung in die Technik des Messens mit Dehnmessstreifen

White A.A., Panjabi M.M.: Clinical biomechanics of the spine

Nigg, B.: Biomechanics of the musculo-skeletal system

Online Hilfe von Mathworks: https://de.mathworks.com/help/matlab/

• Structural characterization by photons, neutrons and electrons (in particular X-ray and neutron scattering, electron microscopy, tomography)
• Mechanical and thermodynamical characterization methods (indenter measurements, mechanical compression and tension tests, specific heat measurements)
  

• Characterization of optical, electrical and magnetic properties (spectroscopy, electrical conductivity and magnetometry)

  
  

William D. Callister und David G. Rethwisch, Materialwissenschaften und Werkstofftechnik, Wiley&Sons, Asia (2011).

William D. Callister, Materials Science and Technology, Wiley& Sons, Inc. (2007).

• Vorkenntnisse aus „ Diskretisierungsmethoden der Mechanik“ sind empfohlen
• Ein Überblick über die gängigsten numerischen Verfahren im Bereich der Biomechanik und Medizintechnik wird vermittelt.
• Grundkenntnissen aus verschiedenen Disziplinen (Mechanik, Mathematik, Programmierung…) werden kombiniert um eine geschlossene Beispielfragestellung zu beantworten
• Die Vorlesung umfasst analytische Ansätze, rheologische Modelle und Finite Elemente Methoden
• Die vermittelten theoretischen Ansätze werden im Laufe der Vorlesung und im Rahmen von Hausaufgaben in praktische Übungen angewandt.
• Der kritische Blick auf die Möglichkeiten und Limitationen der Modellrechnung im Bereich humaner Anwendungen wird geschult.

Hauger W., Schnell W., Gross D., Technische Mechanik, Band 3: Kinetik, Springer-Verlag Berlin Heidelberg, 12. Auflage, 2012

Huber G., de Uhlenbrock A., Götzen N., Bishop N., Schwieger K., Morlock MM., Modellierung, Simulation und Optimierung, Handbuch Sportbiomechanik, Gollhofer A., Müller E., Hofmann Verlag, Schorndorf, 148-69, 2009

At the beginning of the semester, the participants receive a research question from medical engineering or related fields, which they have to work on independently. The researched results are summarised in a written report and presented in a lecture. The evaluation is 30:70 (report:presentation). The participants must secretly evaluate each other and these evaluations are included in the final grade. The presentations are discussed directly afterwards in terms of presentation style, appearance and language.

• Differential equations for momentum-, heat and mass transfer   
• Examples for simplifications of the Navier-Stokes Equations 
• Unsteady momentum transfer
  
• Free shear layer, turbulence and free jets
  
• Flow around particles - Solids Process Engineering
  
• Coupling of momentum and heat transfer - Thermal Process Engineering
  
• Rheology – Bioprocess Engineering
• Coupling of momentum- and mass transfer – Reactive mixing, Chemical Process Engineering 
• Flow threw porous structures - heterogeneous catalysis
  
• Pumps and turbines - Energy- and Environmental Process Engineering 
• Wind- and Wave-Turbines - Renewable Energy
• Introduction into Computational Fluid Dynamics
  
  

1. Brauer, H.: Grundlagen der Einphasen- und Mehrphasenströmungen. Verlag Sauerländer, Aarau, Frankfurt (M), 1971.
2. Brauer, H.; Mewes, D.: Stoffaustausch einschließlich chemischer Reaktion. Frankfurt: Sauerländer 1972.
3. Crowe, C. T.: Engineering fluid mechanics. Wiley, New York, 2009.
4. Durst, F.: Strömungsmechanik: Einführung in die Theorie der Strömungen von Fluiden. Springer-Verlag, Berlin, Heidelberg, 2006.
5. Fox, R.W.; et al.: Introduction to Fluid Mechanics. J. Wiley & Sons, 1994.
6. Herwig, H.: Strömungsmechanik: Eine Einführung in die Physik und die mathematische Modellierung von Strömungen. Springer Verlag, Berlin, Heidelberg, New York, 2006.
7. Herwig, H.: Strömungsmechanik: Einführung in die Physik von technischen Strömungen: Vieweg+Teubner Verlag / GWV Fachverlage GmbH, Wiesbaden, 2008.
8. Kuhlmann, H.C.:  Strömungsmechanik. München, Pearson Studium, 2007
9. Oertl, H.: Strömungsmechanik: Grundlagen, Grundgleichungen, Lösungsmethoden, Softwarebeispiele. Vieweg+ Teubner / GWV Fachverlage GmbH, Wiesbaden, 2009.
10. Schade, H.; Kunz, E.: Strömungslehre. Verlag de Gruyter, Berlin, New York, 2007.
11. Truckenbrodt, E.: Fluidmechanik 1: Grundlagen und elementare Strömungsvorgänge dichtebeständiger Fluide. Springer-Verlag, Berlin, Heidelberg, 2008.
12. Schlichting, H. : Grenzschicht-Theorie. Springer-Verlag, Berlin, 2006.
13. van Dyke, M.: An Album of Fluid Motion. The Parabolic Press, Stanford California, 1882.  

Müller-Esterl, Biochemie, Spektrum Verlag, 2010; 2. Auflage

Löffler, Basiswissen Biochemie, 7. Auflage, Springer, 2008

Topics to be covered include:

1.    Introduction (Importance, nomenclature, relations)

2.    Biological materials

2.1  Basics (components, testing methods)

2.2  Bone (composition, development, properties, influencing factors)

2.3  Cartilage (composition, development, structure, properties, influencing factors)

2.4  Fluids (blood, synovial fluid)

3     Biological structures

3.1  Menisci of the knee joint

3.2  Intervertebral discs

3.3  Teeth

3.4  Ligaments

3.5  Tendons

3.6  Skin

3.7  Nervs

3.8  Muscles

4.    Replacement materials

4.1  Basics (history, requirements, norms)

4.2  Steel (alloys, properties, reaction of the body)

4.3  Titan (alloys, properties, reaction of the body)

4.4  Ceramics and glas (properties, reaction of the body)

4.5  Plastics (properties of PMMA, HDPE, PET, reaction of the body)

4.6  Natural replacement materials

Knowledge of composition, structure, properties, function and changes/adaptations of biological and technical materials (which are used for replacements in-vivo). Acquisition of basics for theses work in the area of biomechanics.

Hastings G and Ducheyne P.: Natural and living biomaterials. Boca Raton: CRC Press, 1984.

Williams D.: Definitions in biomaterials. Oxford: Elsevier, 1987.

Hastings G.: Mechanical properties of biomaterials: proceedings held at Keele University, September 1978. New York: Wiley, 1998.

Black J.: Orthopaedic biomaterials in research and practice. New York: Churchill Livingstone, 1988.

Park J.  Biomaterials: an introduction. New York: Plenum Press, 1980.

Wintermantel, E. und Ha, S.-W : Biokompatible Werkstoffe und Bauweisen. Berlin, Springer, 1996.

- Structure and properties of polymers

- Structure of macromolecules

  Constitution, Configuration, Conformation, Bonds, Synthesis, Molecular weihght distribution

- Morphology

  amorph, crystalline, blends

- Properties

  Elasticity, plasticity, viscoelacity

- Thermal properties

- Electrical properties

- Theoretical modelling

- Applications

Manufacturing of Polymers: General Properties; Calendering; Extrusion; Injection Moulding; Thermoforming, Foaming; Joining

Designing with Polymers: Materials Selection; Structural Design; Dimensioning

Osswald, Menges: Materials Science of Polymers for Engineers, Hanser Verlag
Crawford: Plastics engineering, Pergamon Press
Michaeli: Einführung in die Kunststoffverarbeitung, Hanser Verlag

Konstruieren mit Kunststoffen, Gunter Erhard , Hanser Verlag

Topics to be covered include:

1.    Introduction (history, definitions, background importance)

2.    Bone (anatomy, properties, biology, adaptations in femur, tibia, humerus, radius)

3.    Spine (anatomy, biomechanics, function, vertebral bodies, intervertebral disc, ligaments)

3.1  The spine in its entirety

3.2  Cervical spine

3.3  Thoracic spine

3.4  Lumbar spine

3.5  Injuries and diseases

4.    Pelvis (anatomy, biomechanics, fracture treatment)

5     Fracture Healing

5.1  Basics and biology of fracture repair

5.2  Clinical principals and terminology of fracture treatment

5.3  Biomechanics of fracture treatment

5.3.1    Screws

5.3.2    Plates

5.3.3    Nails

5.3.4    External fixation devices

5.3.5    Spine implants

Cochran V.B.: Orthopädische Biomechanik

Mow V.C., Hayes W.C.: Basic Orthopaedic Biomechanics

White A.A., Panjabi M.M.: Clinical biomechanics of the spine

Nigg, B.: Biomechanics of the musculo-skeletal system

Schiebler T.H., Schmidt W.: Anatomie

Platzer: dtv-Atlas der Anatomie, Band 1 Bewegungsapparat

The course deals with the application of biotechnological engineering principles for re-generation of human tissues. The main topics are "tissue engineering" for the generation of "artificial organs" such as cartilage, liver, blood vessel etc., and their applications:

• Introduction (historical development, examples for medical and technical applications, commercial aspets)

• Cell specific fundamentals (cell physiology, biochemistry, metabolism, special requirements for cell cultivation "in vitro")

• Process specific fundamentals (requirements for culture systems, examples for reactor design, mathematical modelling, process and control strategies)

• Examples for applications for clinical applications, drug testing and material testing

The fundamentals will be presented by the lecturers.

The "state of the art" of specific applications will be exploited by the students based on selected papers and presented during the course.

Regenerative Biology and Medicine (Taschenbuch) von David L. Stocum; Academic Pr Inc; ISBN-10: 0123693713 ,  ISBN-13: 978-0123693716  

Discussion of current research topics for tissue engineering and regenerative medicine by invited experts

Regenerative Biology and Medicine (Taschenbuch) von David L. Stocum; Academic Pr Inc; ISBN-10: 0123693713 ,  ISBN-13: 978-0123693716 

Fundamentals of Tissue Engineering and Regenerative Medicine von Ulrich Meyer (Herausgeber), Thomas Meyer (Herausgeber), Jörg Handschel (Herausgeber), Hans Peter Wiesmann (Herausgeber): Springer, Berlin; ISBN-10: 3540777547;  ISBN-13: 978-3540777540

- imaging systems
- computer aided surgery
- medical sensor systems
- medical information systems
- regulatory affairs
- standard in medical technology
The students will work in groups to apply the methods introduced during the lecture using problem based learning.

Bernhard Priem, "Visual Computing for Medicine", 2014
Heinz Handels, "Medizinische Bildverarbeitung", 2009 (https://katalog.tub.tuhh.de/Record/745558097)
Valery Tuchin, "Tissue Optics - Light Scattering Methods and Instruments for Medical Diagnosis", 2015
Olaf Drössel, "Biomedizinische Technik - Medizinische Bildgebung", 2014
H. Gross, "Handbook of Optical Systems", 2008 (https://katalog.tub.tuhh.de/Record/856571687)
Wolfgang Drexler, "Optical Coherence Tomography", 2008
Kramme, "Medizintechnik", 2011
Thorsten M. Buzug, "Computed Tomography", 2008
Otmar Scherzer, "Handbook of Mathematical Methods in Imaging", 2015
Weishaupt, "Wie funktioniert MRI?", 2014
Paul Suetens, "Fundamentals of Medical Imaging", 2009
Vorlesungsunterlagen

- kinematics
- calibration
- tracking systems
- navigation and image guidance
- motion compensation
The seminar extends and complements the contents of the lecture with respect to recent research results.

Spong et al.: Robot Modeling and Control, 2005
Troccaz: Medical Robotics, 2012
Further literature will be given in the lecture.

Fundamentals of Nonlinear Dynamics

• One dimensional problems
  • Linear Stability
  • Local Bifurcations
  • Synchronisation
    
• Two dimensional problems
  • Limit Cycles
  • Global Bifurcations
• Chaos
  • Lorenz Equations
  • Fractals and Strange Attractors
    
  • Predictability and Horizons

• Introduction (historical view and trends in microelectronics)
• Basics in material science (semiconductor, crystal, Miller indices, crystallographic defects)
• Crystal fabrication (crystal pulling for Si and GaAs: impurities, purification, Czochralski , Bridgeman and float zone process)
• Wafer fabrication (process flow, specification, SOI)
• Fabrication processes

• Doping (energy band diagram, doping, doping by alloying, doping by diffusion: transport processes, doping profile, higher order effects and process technology, ion implantation: theory, implantation profile, channeling, implantation damage, annealing and equipment)

• Oxidation (silicon dioxide: structure, electrical properties and oxide charges, thermal oxidation: reactions, kinetics, influences on growth rate, process technology and equipment, anodic oxidation, plasma oxidation, thermal oxidation of GaAs)

• Deposition techniques (theory: nucleation, film growth and structure zone model, film growth process, reaction kinetics, temperature dependence and equipment; epitaxy: gas phase, liquid phase, molecular beam epitaxy; CVD techniques: APCVD, LPCVD, deposition of metal silicide, PECVD and LECVD; basics of plasma, equipment, PVD techniques: high vacuum evaporation, sputtering)

• Structuring techniques (subtractive methods, photolithography: resist properties, printing techniques: contact, proximity and projection printing, resolution limit, practical issues and equipment, additive methods: liftoff technique and electroplating, improving resolution: excimer laser light source, immersion lithography and phase shift lithography, electron beam lithography, X-ray lithography, EUV lithography, ion beam lithography, wet chemical etching: isotropic and anisotropic, corner undercutting, compensation masks and etch stop techniques; dry etching: plasma enhanced etching, backsputtering, ion milling, chemical dry etching, RIE, sidewall passivation)

• Process integration (CMOS process, bipolar process)

• Assembly and packaging technology (hierarchy of integration, packages, chip-on-board, chip assembly, electrical contact: wire bonding, TAB and flip chip, wafer level package, 3D stacking)

   

S.K. Ghandi: VLSI Fabrication principles - Silicon and Gallium Arsenide, John Wiley & Sons

S.M. Sze: Semiconductor Devices - Physics and Technology, John Wiley & Sons

U. Hilleringmann: Silizium-Halbleitertechnologie, Teubner Verlag

H. Beneking: Halbleitertechnologie - Eine Einführung in die Prozeßtechnik von Silizium und III-V-Verbindungen, Teubner Verlag

K. Schade: Mikroelektroniktechnologie, Verlag Technik Berlin

S. Campbell: The Science and Engineering of Microelectronic Fabrication, Oxford University Press

P. van Zant: Microchip Fabrication - A Practical Guide to Semiconductor Processing, McGraw-Hill

• Grundlagen der Regelungstechnik
• Control systems theory and design
  
  

- B. Siciliano, O. Khatib. "Handbook of Robotics. Part A: Robotics Foundations",

Springer (2008).

• Prediction error method
  
• Linear and nonlinear model structures
• Nonlinear model structure based on multilayer perceptron network
• Approximate predictive control based on multilayer perceptron network model
• Subspace identification

• Lennart Ljung, System Identification - Theory for the User, Prentice Hall 1999
• M. Norgaard, O. Ravn, N.K. Poulsen and L.K. Hansen, Neural Networks for Modeling and Control of Dynamic Systems, Springer Verlag, London 2003
• T. Kailath, A.H. Sayed and B. Hassibi, Linear Estimation, Prentice Hall 2000

• Optimal regulator problem with finite time horizon, Riccati differential equation
• Time-varying and steady state solutions, algebraic Riccati equation, Hamiltonian system
• Kalman’s identity, phase margin of LQR controllers, spectral factorization
• Optimal state estimation, Kalman filter, LQG control
• Generalized plant, review of LQG control
• Signal and system norms, computing H2 and H∞ norms
• Singular value plots, input and output directions
• Mixed sensitivity design, H∞ loop shaping, choice of weighting filters

• Case study: design example flight control
• Linear matrix inequalities, design specifications as LMI constraints (H2, H∞ and pole region)
• Controller synthesis by solving LMI problems, multi-objective design
• Robust control of uncertain systems, small gain theorem, representation of parameter uncertainty

• Werner, H., Lecture Notes: "Optimale und Robuste Regelung"
• Boyd, S., L. El Ghaoui, E. Feron and V. Balakrishnan "Linear Matrix Inequalities in Systems and Control", SIAM, Philadelphia, PA, 1994
• Skogestad, S. and I. Postlewhaite "Multivariable Feedback Control", John Wiley, Chichester, England, 1996
• Strang, G. "Linear Algebra and its Applications", Harcourt Brace Jovanovic, Orlando, FA, 1988
• Zhou, K. and J. Doyle "Essentials of Robust Control", Prentice Hall International, Upper Saddle River, NJ, 1998

I. Introduction

• Innovation and service marketing (importance of innovative products and services, model, objectives and examples of innovation marketing, characteristics of services, challenges of service marketing)

• patterns of industrial development, patent and technology portfolios

• objectives and challenges of strategic foresight, scenario analysis, Delphi method

• Role of users in the innovation process, user communities, user innovation toolkits, lead users analysis

• Conjoint Analysis, Kano, QFD, Morphological Analysis, Blueprinting

• Basics of Pricing, Value-based pricing, Pricing models
  

• Basics of Sales Management, Assessing Customer Value, Planning Customer Visits

• Diffusion of Innovations, Communication Objectives, Communication Instruments

Mohr, J., Sengupta, S., Slater, S. (2014). Marketing of high-technology products and innovations, third edition, Pearson education. ISBN-10: 1292040335 . Chapter 6 (188-210), Chapter 7 (227-256), Chapter 10 (352-365), Chapter 12 (419-426).

Crawford, M., Di Benedetto, A. (2008). New  products management, 9th edition, McGrw Hill, Boston et al., 2008

Christensen, C. M. (1997). Innovator's Dilemma: When New Technologies Cause Great Firms to Fail, Harvard Business Press, Chapter 1: How can great firms fail?,pp. 3-24.

Hair, J. F., Bush, R. P., Ortinau, D. J. (2009). Marketing research. 4^th edition, Boston et al., McGraw Hill

Tidd; J. & Hull, Frank M. (Editors) (2007) Service Innovation, London

Von Hippel, E.(2005). Democratizing Innovation, Cambridge: MIT Press

• Introduction: state-of-the-art and development trends in the biotechnology, introduction to the lecture  
• Enzyme kinetics: Michaelis-Menten, differnt types of enzyme inhibition, linearization, conversion, yield, selectivity (Prof. Liese)
• Stoichiometry:  coefficient of respiration, electron balance, degree of reduction, coefficient of yield, theoretical oxygen demand (Prof. Liese)
  
• Microbial growth kinetic: batch- and chemostat culture (Prof. Zeng)
• Kinetic of subtrate consumption and product formation (Prof. Zeng)
• Rheology: non-newtonian fluids, viscosity, agitators, energy input (Prof. Liese)
• Transport process in a bioreactor (Prof. Zeng)
• Technology of sterilization (Prof. Zeng)
• Fundamentals of bioprocess management: bioreactors and calculation of batch, fed-batch and continuouse bioprocesses
  (Prof. Zeng/Prof. Liese)
• Downstream technology in biotechnology: cell breakdown, zentrifugation, filtration, aqueous two phase systems (Prof. Liese)
  

K. Buchholz, V. Kasche, U. Bornscheuer: Biocatalysts and Enzyme Technology, 2. Aufl. Wiley-VCH, 2012

H. Chmiel: Bioprozeßtechnik, Elsevier, 2006

R.H. Balz et al.: Manual of Industrial Microbiology and Biotechnology, 3. edition, ASM Press, 2010 

H.W. Blanch, D. Clark: Biochemical Engineering, Taylor & Francis, 1997 

P. M. Doran: Bioprocess Engineering Principles, 2. edition, Academic Press, 2013

1. Introduction (Prof. Liese, Prof. Zeng)

2. Enzymatic kinetics (Prof. Liese)

3. Stoichiometry I + II (Prof. Liese)

4. Microbial Kinetics I+II (Prof. Zeng)

5. Rheology (Prof. Liese)

6. Mass transfer in bioprocess (Prof. Zeng)

7. Continuous culture (Chemostat) (Prof. Zeng)

8. Sterilisation (Prof. Zeng)

9. Downstream processing (Prof. Liese)

In this course fermentation and downstream technologies on the example of the production of an enzyme by means of a recombinant microorganism is learned. Detailed characterization and simulation of enzyme kinetics as well as application of the enzyme in a bioreactor is carried out.

The students document their experiments and results in a protocol. 

• Systematic analysis and planning of the design process for products combining a multitude of disciplines
• Structure of the engineering process with focus on engineering steps (task-definition, functional decomposition, physical principles, elements for solution, combination to systems and products, execution of design, component-tests, system-tests, product-testing and qualification/validation)
• Creative methods (Basics, methods like lead-user-method, 6-3-5, BrainStorming, Intergalactic Thinking, … - Applications in examples all around mechatronics topics)
• Several design-supporting methods and tools (functional strcutures, GALFMOS, AEIOU-method, GAMPFT, simulation and its application, TRIZ, design for SixSigma, continous integration and testing, …)
• Evaluation and final selection of solution (technical and business-considerations, preference-matrix, pair-comparision), dealing with uncertainties, decision-making
• Value-analysis
• Derivation of architectures and architectural management
  
• Project-tracking and -guidance (project-lead, guiding of employees, organization of multidisciplinary R&D departments, idea-identification, responsibilities and communication)
• Project-execution methods (Scrum, Kanbaan, …)
• Presentation-skills
• Questions of aesthetic product design and design for subjective requirements (industrial design, color, haptic/optic/acoustic interfaces)
• Evaluation of selected methods at practical examples in small teams

• Definition folgt...
• Pahl, G.; Beitz, W.; Feldhusen, J.; Grote, K.-H.: Konstruktionslehre: Grundlage erfolgreicher Produktentwicklung, Methoden und Anwendung, 7. Auflage, Springer Verlag, Berlin 2007
• VDI-Richtlinien: 2206; 2221ff